化学療法剤の研究 第33報

2-Hydrazinothiazole類について

抄録

2-β-Acetylhydrazinothiazoles were prepared by the application of α-haloketones to 1-acetylthiosemicarbazide and the hydrolysis of the thiazoles thereby obtained with diluted hydrochloric acid gave several kinds of 2-hydrazinothiazoles. However, the corresponding 2-hydrazino compound could not be isolated from 2-β-acetylhydrazino-4-methylthiazole, and the evaporation of the hydrolyzed solution under a diminished pressure to dryness afforded 2-amino-5-methyl-1, 3, 4-thiadiazine hydrochloride in a good yield. These compound were prepared in order to test their activities against tubercle bacilli.