YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
ACTH検定法に関する研究
伊藤 四十二高畠 英伍
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1953 年 73 巻 7 号 p. 696-700

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Using rats pretreated with a preparation of adrenal cortical extract (Adrex “Sankyo”) so as to suppress the secretion of ACTH from cerebral hypophysis, it was examined whether this could be used for the assay of ACTH. Sixteen hours after subcutaneous injection of Adrex, corresponding to 80g. of adrenal, with 2mg. of ascorbic acid, the rat was anesthetized with pentobarbital, its left adrenal taken out, and the test solution was injected intravenously. After 1 hour, its right adrenal was taken out and the ascorbic acid concentration in the two adrenals was compared. The difference value itself and the decreased rate were taken as the respective responses and analyzed statistically. In 0.625-5.0γ/100g. dose, lineality of the log dose-response curve was observed but the value λ was found to be too large and varied.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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