1, 3, 4-Thiadiazole誘導体に関する研究 (第7報)
2-Phenylthiadiazole誘導体の合成
1953 年 73 巻 7 号 p. 701-705
詳細
1953 年 73 巻 7 号 p. 701-705
The thioformyl compounds, obtained by the application of potassium dithioformate to the hydrazides of benzoic, phenylacetic, and o- and p-hydroxybenzoic acids, were cyclized with conc. sulfuric acid to 2-phenyl-, 2-benzyl-, 2-o-hydroxyphenyl-, and 2-p-hydroxyphenyl-1, 3, 4-thiadiazole, respectively. Nitration of 2-phenylthiadiazole gave three kinds of nitro derivatives and that of m.p. 200° was confirmed as the p-substituent, that of m.p. 132° as the m-, and that of m.p. 113° as the o-substituent. Relationship between the ultraviolet absorption curve and structure of nitro and amino derivatives of 2-phenylthiadiazole was observed. Nitration of 2-amino-5-phenylthiadiazole first yielded a nitramino compound which underwent transition by sulfuric acid to 2-amino-5-p-nitro-phenylthiadiazole.
