YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
(Vitamin B1及び諸関係化合物の研究 第47報)
Allithiamine同族体の合成 その3
川崎 弌
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1953 年 73 巻 7 号 p. 712-716

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By the application of alkyl alkylthiosulfinate or sodium alkylthiosulfate to the acetyl, propionyl, and benzoyl esters of the thiol-type vitamin B1, 24 kinds of 2-[2′-methyl-4′-aminopyrimidyl-(5′)]-methylformamino-5-acyloxy-Δ2-pentenyl-(3) alkyl disulfide (II) (O-acylthiamine alkyl disulfide) were prepared. (II) can also be obtained by the acylation of thiamine alkyl disulfide (I) in pyridine. All the compounds of (II) series were found to be approximately equal to vitamin B1 in preventing vitamin B1 deficiency in Uroloncha domestica.

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