YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
試験管内に於ける諸種有機化合物の抗菌作用に関する研究 (第5報)
藤川 福二郎中島 邦夫徳岡 曉正人長 有平中沢 昭三尾松 徳五郎隅山 陣
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1953 年 73 巻 7 号 p. 740-743

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Growth inhibitory action against three kinds of bacteria was tested in 61 kinds of compounds. The compounds that were effective in completely inhibiting the growth of Micrococcus pyogenes var. aureus in 80, 000 dilution were 5, 4′-dichloro-2, 4-dihydroxy-diphenylmethane, 2, 4-dihydroxy-5-heptylbenzaldehyde, 2, 4-dihydroxy-3-chloro-5-ethylbenzaldehyde thiosemicarbazone, 2, 4-dihydroxy-3-chloro-5-butylbenzaldehyde thiosemicarbazone, and α-collatolic acid dithiosemicarbazone, in 160, 000 dilution by 2, 4-dihydroxy-3-chloro-5-hexylbenzaldehyde and methyl monochloroisohaematommate thiosemicarbazone, in 320, 000 dilution by 2, 4-dihydroxy-5-isoamylbenzaldehyde thiosemicarbazone, and in 640, 000 dilution by 2, 4-dihydroxy-3-chloro-5-hexylbenzaldehyde thiosemicarbazone. The compounds effective in inhibiting growth of Bacillus subtilis in 80, 000 dilution were 5, 4′-dichloro-2, 4-dihydroxydiphenylmethane, 2, 4-dihydroxy-3-chloro-5-ethylbenzaldehyde thiosemicarbazone, 2, 4-dihydroxy-3-chloro-5-butylbenzaldehyde thiosemicarbazone, α-collatolic acid dithiosemicarbazone, and methyl monochloroisohaematommate thiosemicarbazone, in 160, 000 dilution by 2, 4-dihydroxy-5-isoamylbenzaldehyde thiosemicarbazone, and in 320, 000 dilution by 2, 4-dihydroxy-3-chloro-5-hexylbenzaldehyde thiosemicarbazone. Some compounds were able to inhibit the growth of Escherichia coli communior in 10, 000 dilution but none were effective in higher dilutions.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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