YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
白癬菌に対する化学療法 (第2報)
界面活性剤の抗黴作用及び白癬菌化学療法剤に対する協力作用
小沢 光榎本 金吾
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1953 年 73 巻 7 号 p. 754-756

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Antifungal action, in vitro of various surface active agents against Trichophyton was tested by which cationic agent, trimethylcetylammonium halide, and anionic agent, sodium p-laurylphenylsulfonate, were found to possess excellent properties. Nonionic surface active agents were found to be practically devoid of antifungal activities. The increase in the efficacy of surface active agents by the concurrent use of 2-dimethylamino 6-(β-diethylaminoethoxy)-benzothiazole dihydrochloride (Asterol), a chemotherapeutic for Trichophyton, was found to be 3-30 times, and the surface active agents that failed to show any efficacy by themselves were also found to have acquired such efficacy. This was assumed to be due to the increase of permeability of fungal membrane of Trichophyton by surface active agents.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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