YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Diphenyl Etherを基核とする数種のアンモニウム化合物の合成
富田 真雄高橋 孝三
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1953 年 73 巻 7 号 p. 760-763

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In order to test the curare-like action, following three ammonium compounds possessing diphenyl ether as the functional group were prepared: 4, 4′-bis(Dimethylamino)-diphenyl ether dimethiodide (II), 4, 4′-bis(dimethylaminomethyl)diphenyl ether dimethiodide (III), and 2-methoxy-5, 4′-bis(dimethylaminomethyl)diphenyl ether dimethiodide (IV). For comparison, 4, 4′-bis(dimethylaminomethyl)biphenyl dimethiodide (V) was also prepared. For their preparation, diphenyl ether, 2-methoxydiphenyl ether, or biphenyl was derived to bis(chloromethyl) or a corresponding bromo derivative to which was applied liquid dimethylamine. Methyl iodide was then applied to the dimethylaminomethyl derivatives thereby formed to the corresponding objective compounds.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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