1954 年 74 巻 10 号 p. 1052-1055
Formation of a piperazine ring by the fusion of morpholine salts and amine hydrochlorides was examined. The reaction was found to proceed comparatively well with the hydrochloride of aromatic amines, such as aniline, at 220-240°, to give phenylpiperazines, as in the case of diethanolamines. In the case of ammonium chloride and hydrochloride of aliphatic amines, higher temperature was necessary, which effected partial dealkylation and the yield of piperazines were not so good.