海人草成分の薬理学的研究 (第2報)

抄録

Pharmacological action of kainic acid, the effective principle of Digenea, was further examined. Kainic acid does not inhibit the gill respiration of a clam (Corbicula leana Prime) or the respiration of the tissues of hog ascaris (Ascaris suilla), but inhibits the dehydrogenase action in the muscle. Injection of 1-2mg./kg. of kainic acid in rabbits inhibited heart motion, damaged the kidney and liver, and affected changes in the blood cell counts of the plasma. In examining the action of kainic acid on smooth muscles, it was found that the vomiting that appears on subcutaneous injection in puppies is the direct action of kainic acid on the smooth muscles and irritation of the vomiting center.