イソヒノリン誘導体の合成研究 (第31報)

Furo [3,2-c] pyridine誘導体の合成

抄録

Although thienopyridines, the benzene portion of the isoquinoline ring substituted with thiophene, have been synthesized, the compound in which the benzene portion had been substituted with furan, i, e. furo [3, 2-c] pyridines have not been synthesized as yet and this was attempted. Furylnitroethylene was reduced with lithium aluminum hydride to β-2-furylethylamine which was condensed by the Schotten-Baumann method respectively with benzoyl, 3, 4-dimethoxybenzoyl, 3, 4-methylenedioxybenzoyl, and 3-methoxy-4-benzyloxybenzoyl chloride to the corresponding acid amides, and were finally cyclized by the Bischler-Napieralski reaction to the objective 1-aryl-3, 4-dihydrofuro [3, 2-c] pyridines.