YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
イソヒノリン誘導体の合成研究 (第32報)
Thieno-[3,2-c] pyridine誘導体の合成並びに薬理作用
亀谷 哲治伊藤 酉一青沼 繁
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1954 年 74 巻 12 号 p. 1301-1304

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Of the 6 kinds of theoretically available thienopyridines, several kinds of 1-aryl-3, 4-dihydrothieno [3, 2-c] pyridines were obtained by deriving 2-thienaldehyde to β-2-thienylethylamine to which were respectively condensed 3, 4-dimethoxy-, 3, 4-methylenedioxy-, and 3-methoxy-4-benzyloxy-benzoyl chloride to the amide, and finally cyclized to the objective compounds. Pharmacological action of three kinds of thienopyridines and furopyridines was examined and 1-(3′-methoxy-4′-benzyloxyphenyl)-3, 4-dihydrofuro [3, 2-c] pyridine was found to cause a marked intestinal contraction and inhibition of intestinal movements, and to possess oxytocic action about one-fiftieth that of Oxytocin.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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