1954 年 74 巻 12 号 p. 1305-1309
Growth inhibition of Staphylococci (Terashima strain) was examined with 30 kinds of cyanine dyes, including aminovinyl, merocarbocyanine, methineoxonol, and benzal compounds. It was found that the aminovinyl and its allied series of dyes were effective while methineoxonol dyes also showed a slight growth inhibition. The aminovinyl compounds were also effective against coli bacilli. Effect of dyes on the tissue permeability was examined by mixing these dyes with black ink with or without hyaluronidase and injecting the fluid on rabbit's back and determining the size of the blackened area. It was thereby found that 5-(ω-benzoylvinyl)-thiobarbituric acid and methiodides of 2-ω-trichloromethylvinylpyridine and -quinoline gave good biological effect.