2-Benzimidazolethiol誘導体の合成

抄録

1) Reaction between 2-benzimidazolethiol and alkyl halide was examined and alkyl derivatives of 2-benzimidazolethiols listed in Tables II, III, and IV were synthesized by heating those compounds in pyridine. Some observations were made on the reaction mechanisms.
2) In these reactions, the alkylation was found to proceed approximately step by step and it was found that the order of the reactivity of each atomic group against alkylation agent, i.e. electrophilic reagent, in the 2-benzimidazolethiol derivatives to be -SH>-N=(ring nitrogen)>-N_R- (ring nitrogen).