YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
含窒素環化合物の合成 (第94報)
5-アミノチアゾール誘導体について その3
高橋 酉藏坂本 貞文島田 惠年
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1954 年 74 巻 12 号 p. 1377-1380

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1) Condensation of 2-hydroxy-4-phenyl-5-aminothiazole and benzaldehyde yielded the 5-benzalamino derivative, which was also obtained by the reaction of α-aminophenylacetonitrile, benzaldehyde, and carbonyl sulfide. Use of p-acetaminobenzaldehyde in place of benzaldehyde in this case results the formation of the 5-p-acetaminobenzalamino derivative. A series of 2-alkoxy or -allyloxy derivatives were prepared by the application of alkyl halide or allyl bromide to the sodium salt of these Schiff's bases.
2) 2-Mercapto-4-methyl-5-benzalaminothiazole was obtained by the reaction of α-aminopropionitrile, benzaldehye, and carbon disulfide.
3) Application of benzaldehyde or p-acetaminobenzaldehyde to 2-mercapto-4-phenyl-5-aminothiazole yielded the corresponding Schiff's bases which were converted to the 2-alkyl (or allyl) thiol derivatives.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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