テラマイシン及び関連化合物の研究 (第3報)
6-Acetylsalicylic Acidについて
1954 年 74 巻 5 号 p. 466-470
詳細
1954 年 74 巻 5 号 p. 466-470
From the alkaline degradation products of Terramycin, Kuhn and Dury isolated a phenolic ketocarboxylic acid and confirmed its structure as 6-acetylsalicylic acid by its conversion to methyl 2-methoxy-6-acetylbenzoate. However, the synthesis of 6-acetylsalicylic acid has not been reported. The authors synthesized this compound through the route described in Table I. From the study of infrared absorption spectra of 6-acetylsalicylic acid and its derivatives, it was found that these compounds exhibit a ketolactol tautomerism represented by the general formulae: The results obtained are summarised in Tables II and III.
