YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
アミノ酸の拮抗物質の研究 (第3報)
Lactobacillus arabinosusにおけるカナバニン及びカナリンとアルギニンの拮抗について
鈴木 友二村岡 三郎小延 鑑一
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1954 年 74 巻 5 号 p. 537-540

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Lactobacillus arabinosus 17-5 can synthesize arginine in a culture medium containing glutamic acid and pyridoxal but canavanine can completely inhibit growth under such cultural conditions in an extremely low concentration (1.76×10-5 moles). In this case, the addition of arginine makes it necessary to have higher concentration of canavanine for growth inhibition. The metabolic products which can recover growth inhibition of canavanine include arginine, which is the best, citrulline, ornithine, and glutamic acid, the strength becoming weaker in this order. This order seems to have some relation to the arginine metabolism of L. arabinosus. In the case of lower concentrations of canavanine (1-50 γ), simple extension of culture period can recover the growth. Canaline shows growth inhibitive action in culture medium in which arginine is synthesized from glutamic acid but does not show practically any inhibition on the utilization of ornithine, citrulline and arginine.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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