アミノ酸の拮抗物質の研究 (第4報)

微生物のアルギニン要求性とカナバニンによる増殖抑制との関連について

抄録

Arginine requirement and growth inhibition by canavanine were examined in the parent strains and arginine-requiring mutants of Streptococcus faecalis, Leuconostoc mesenteroides, Lactobacillus arabinosus, Lact. casei, Lact. fermenti, Escherichia coli No. 1, Staphylococcus aureus 209 P, and Salmonella enteritidis 1891. It was thereby found that Strept. faecalisand Leuc. mesenteroides required only arginine and did not receive inhibition by canavanine, while other strains were able to grow by synthesizing arginine from inorganic substances or from ornithine and citrulline in the medium and their growth was easily inhibited by canavanine. Neither canavanine, canalin, nor homoserine was able to substitute for arginine. The reaction center of the growth inhibition by canavanine was discussed from the experimental results of the writer and those of Snell and Walker.