チアツオール誘導体の研究 (第7報)

β-(2´-Amino-4´-methyl-5´-thiazolyl)-ethylisothiouronium塩に就いてその2

抄録

The new substance of m.p. 241-242°, described in the previous paper, was found to be β-(2′-amino-4′-methyl-5′-thiazolyl)-ethylisothiouronium hydrochloride by its agreement with the substance synthesized by the following two different methods:
1) Reaction between γ-aceto-γ-chloropropyl chloride and thiourea.
2) Alkali treatment of 2-acetylamino-4-methyl-5-acetoxyethylthiazole, obtained from 2-amino-4-methyl-5-hydroxy (or acetoxy)-ethylthiazole, to 2-acetylamino-4-methyl-5-hydroxyethylthiazole, its chlorination to the 5-chloroethyl compound, with subsequent reaction with thiourea and saponification with hydrochloric acid.