化学療法剤の研究 第40報

2-Amino-1,3,4-thiadiazole及び2-Amino-5-methyl-1,3,4-thiadiazoleの製造法について

抄録

1) 2-Amino-1, 3, 4-thiadiazole was prepared from thiosemicarbazide by application of 80% formic acid to 1-formylthiosemicarbazide which was derived to 2-formamino-1, 3, 4-thiadiazole.
2) 1-Acetylthiosemicarbazide was heated with acetic anhydride to form 2-acetamino-5-methyl-1, 3, 4-thiadiazole which was derived to 2-amino-5-methyl-1, 3, 4-thiadiazole.
3) Heating of 1-acetylthiosemicarbazide with 80% formic acid resulted in transacylation with cyclization to form 2-formamino-1, 3, 4-thiadiazole.
4) 5-Substituted 2-acetamino-1, 3, 4-thiadiazole was not generally obtained pure when 1-acylthiosemicarbazide was heated with acetic anhydride.