抗局所麻酔薬の化学的及び薬理学的研究 (第4報)

N¹, N¹-diethyl-及びN¹-ethyl-p-aminobenzenesulfonamideの化学的及び薬理学的研究

抄録

As the compounds possessing structure similar to the procaine antagonist, sulfonamide, N¹, N¹-diethyl-, m.p. 105°, and N¹-ethyl-p-aminobenzenesulfonamide, m.p. 107°, were prepared. The lethal dose, LD₅₀, of the diethyl derivative against mouse was 5.5mg./10g. (subcutaneous injection, Behrens-Kärber method), 31.3±3.29mg./10g. (oral administration. V. d. Waerden method), and that of the monoethyl derivative, 5.1mg./10g. (subcutaneous injection of the hydrochloride, Behrens-Kärber method). The general action of these amides against mouse was ceasure of automatic motion, trembling, and respiratory paralysis. Neither showed any antagonism against procaine in either mouse or rabbit.