合成クラーレ作用物質の研究 (第5報)

Hydroquinone Ether結合を有するBis (2-methyl-1,2,3,4-tetrahydroisoquinoline) 誘導体の合成

抄録

6, 7-Substituted hydroquinone bis (2-methyltetrahydroisoquinolyl-(1)-methyl) ether dimethiodides were prepared in order to examine the influence of the substitutents in the 1-position and the benzene nucleus of the d-tubocurarine molecule on the curare-like effect. The preparation of the compounds followed the method similar to that described in the previous paper. The compounds prepared may be a mixture of stereoisomers since they possess two asymmetric carbons.