除痛剤の合成 (第6報)

カンファン誘導体について

抄録

By the application of α-haloacyl halides to 5-aminocamphor or d-borneol, 3-α-haloacylaminocamphors and d-bornyl α-haloacylates were prepared. Condensation of these haloacyl derivatives with dimethyl- or diethylamine afforded the coresponding 3-α-dialkylaminoacylaminocamphors and d-bornyl α-dialkylaminoacylates. By the application of β-diethylaminoethyl chloride to 3-aminocamphor, 3-β-diethyaminoethylaminocamphor was prepared and by the condensation of β-diethylaminoethyl and β-dimethylaminoethyl chlorides to the sodium salt of d-borneol, the corresponding β-dialkylaminoethyl d-bornyl ethers were obtained.