YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Vitamin B1関係化合物の研究 (第18報)
N-置換-Thiazolidine-2-thione誘導体に対するハロゲンアルキルの作用について
吉田 茂淺井 素次
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1955 年 75 巻 11 号 p. 1389-1391

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Application of alkyl iodide to 3-(2-methyl-4-amino-5-pyrimidylmethyl)-3a-methyltetrahydrofuro [2, 3-d] thiazoline-2-thione (III) and 4-hydroxy-4-methyl-5 β-hydroxyethylthiazolidine-2-thione, and its acyl derivative (IV) affords, according to the amount of the alkyl iodide used and reaction conditions, mono or dihydriodide of thiochromine (II). It was shown in the present series of experiments that (II) is formed from (III) and (IV), respectively through the intermediates (V) and (VI).

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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