横隔膜血管灌流によるクラーレ様作用の検定法に就いて

抄録

1) Potency determination of synthetic curare-active substances was successfully made by the preparation of a blood-perfusion sample of rat diaphragm. Comparison of this method with the existing head-drop and Claude-Bernard methods was made with 8 kinds of polymethylene-bis (3-methyl-6, 7-methylenedioxy-Py-tetrahydroiso quinoline) methiodide and somewhat parallel results were obtained.
2) Of the samples used, the decamethonium compound showed the strongest activity and the relationship between the number of the methylene group and the curare-like action was approximately equal to the rules heretofore reported.
3) There was found no significant relationship between the curare-like action and toxicity.
4) The action of this decamethonium compound is antagonized by neostigmine.