錠剤の研究 (第1報)

錠剤の崩壞時間について

抄録

Tablets were manufactured with the same base but varying the kind, concentration, and amount of the binding agent, and pressure added, and their influence on the crumbling time was examined. In this case, use of sodium arginate as the binding agent resulted in the tablets not crumbling in synthetic gastric juice but rapidly crumbling in synthetic enteric juice and effected enteric coating. Sulfathiazole and Benadryl tablets were prepared with sodium arginate as the binding agent and their blood level was examined after administration of such tablets. The rate of excretion of sulfathiazole was so small that the effect could not be observed but the effect was clearly observed with Benadryl, the maximum blood level being maintained for 5-6 hours.