駆虫薬の研究 第13報
サントニン合成におけるMichael縮合
1955 年 75 巻 4 号 p. 395-399
詳細
1955 年 75 巻 4 号 p. 395-399
The Michael-type condensation of diethyl malonate, methyl cyanoacetate, methyl cyanopropionate, or ethyl acetoacetate with 3-oxo-4, 9-dimethyl-1, 2, 3, 7, 8, 9-hexahydronaphthalene, possessing a linear extended dienone system, results in the specific formation of an equatorial side chain at C6-position. This configuration is the same as that at C7-position of natural santonin and a grave difficulty has been overcome for the synthesis of santonin by this discovery.
