錠剤の研究 (第2報)

錠剤の硬さについて

抄録

Hardness meter for tablets against static pressure using a lever was manufactured on trial and its effect on transition rate of the load, overlapping of the switch, and variation of the load were examined in order to certify the reliability of the hardness meter. On using this hardness meter, the following points were clarified:
1) When the thickness of the tablet was varied, there was a large interaction with the degree of compression, even when same granules are used.
2) As for the die of tabletting, one with a smaller radius of curvature makes soft tablets.
3) As for the relationship between tabletting and crumbling time, (a) use of soft granules does not show any effect of die type between time of crumbling and hardness; but (b) use of hard granules show the effect of die type, and the die of 9mm. diameter and γ′=6.75mm. was found to give tablets of equal hardness which crumble rapidly.