Aconitum-Alkaloide (第7報)

各地産のトリカブト属植物塩基に就いて その2

抄録

Alkaloidal components were extracted from the aconite collected at Toroko (Akita Prefecture) (Ochiai No. 9) and at Gomando (Fukushima Prefecture) (No. 10) yielded, as the crystalline alkaloids, aconitine and Toroko-base I (tentative designation) from the ammonia precipitate, Toroko-bases II, III, and IV (all tentative designations) from the water-soluble portion and jesaconitine (as perchlorate) from the ammonia precipitate. Toroko-base I comes as needle crystals melting at 198-200° (sinters once at 130-140°), [α]_D¹⁰: +77.71° (MeOH), has a benzoyl group, but its composition has not been determined as yet. Toroko-base II comes as needle crystals of m.p. 85-88°, [α]_D¹²: +43.45° (MeOH), agrees with C₂₄H₃₉O₆N, and possesses three methoxyls and one N-methyl (or N-ethyl) group. Toroko-base III, m.p. 325-326° (decomp.), and Toroko-base IV. m.p. 207-209°, have not been characterized as yet.
Ammonia precipitate of No. 10 base yielded jesaconitine, mesaconitine, and a base clearly different from jesaconitine and possessing an anisoyl group and this was tentatively designated as the Gomando-base II. It failed to form a crystalline perchlorate. Another base, possessing a benzoyl group, was obtained as needle crystasls of m.p. 199° (sinters once at 140°), [α]_D²⁰: +76.60. Its mixed fusion with the Toroko-base I showed no depression of the melting point but the analytical values did not agree that it was tentatively designated as the Gomando-base I. A base was obtained as needle crystals of m.p. 320° (decomp.) from the water-soluble portion and was tentatively designated as the Gomando-base III pending clarification of its composition.