鎭痙剤の研究 (第4報)

1, 1-Diphenyl-3-piperidinobutanol Hydrochlorideの薬理作用について

抄録

Pharmacological action of 1, 1-diphenyl-3-piperidinobutanol hydrochloride (No. 3) was examined and following results were obtained:
1) In the tests on antispasmodic activity by the excised guinea pig intestines, No. 3 showed 30-50% activity of atropine sulfate and 50% that of papaverine hydrochloride, and in vivo intestinal tests, it showed approximately 8% the activity of atropine sulfate.
2) The local anesthetic activity of No. 3 was 70% of procaine hydrochloride as inducing anesthetic, and 270% of procaine as surface anesthetic.
3) The side-action of No. 3, as compared to that of atropine sulfate, was less than 1/50 in antisilagogue action, less than 1/60 in vagal cardiac stimulating action, and less than 1/50 in mydriatic action. Its LD₅₀ was 59.7mg./kg. by intravenous injection.