YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
1,4-ナフトキノン2位及び2,3位置換体の抗菌性 (第6報)
Alkyl (aryl) amino-1, 4-naphthoquinone類の抗菌性
池田 仁三郎
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1955 年 75 巻 6 号 p. 649-652

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Amino derivatives of 1, 4-naphthoquinones shown in Table I were prepared and their antibacterial tests were carried out (cf. Table II). Amino derivatives showed antibacterial action against gram-positive bacteria, clearly indicating the effect of a substituent. Introduction of a halogen atom seems to give favorable effect on the antibacterial property. Aliphatic amines show antibacterial action against the gram-negative bacteria. Some of the 2-amino-3-thio-1, 4-naphthoquinones show considerable antibacterial action (Nos. 29 and 30), and it was pointed out that the antibacterial activity of naphthoquinones was due in part to some factors other than that caused by the bonding of such compounds with the -SH group, necessary for bacterial growth.

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