合成鎭痛剤の研究 (第8報)

1-Methyl-4-置換-1,2,5,6-tetrahydropyridine及び1-Methyl-2-置換-1,4,5,6-tetrahydropyridineの合成

抄録

There are several compounds having powerful analgesic action in the series of 1-methyltetrahydropyridines possessing alicyclic radical in 2- or 4-position. These were obtained by the dehydration of hydroxypiperidines, which were prepared by the reaction with Grignard or lithium compounds of corresponding alicyclic compounds on 1-methyl-4-piperidones. The dehydration of 1-methyl-2-hydroxy-2-alicyclic piperidine was also tried but was not successful so far as the conditions employed were concerned.