除痛剤の合成 (第5報)

アミノチクロペンタン誘導体について

抄録

The Grignard reagents prepared from methyl, ethyl, propyl, isopropyl, allyl, butyl, phenyl, benzyl, and cyclohexyl halides were reacted respectively with 2-dimethylamino-methylcyclopentanone and the corresponding 1-alkyl (allyl, phenyl, benzyl, or cyclohexyl)-2-dimethylaminomethylcyclopentanols were prepared. Application of benzoyl, p-nitrobenzoyl, and cinnamoyl chloride to the 1-ethyl, -propyl, -phenyl, -benzyl, and -cyclohexyl derivatlves yielded the corresponding esters. 1-Ethyl-1-p-nitrobenzoyloxy-2-dimethylaminomethylcyclopentanol was reduced to the amino compound and condensed with ethyl chlorocarbonate to 1-ethyl-1-p-ethoxycarbonylamino-benzoyloxy derivative.