ピリダチン誘導体の合成 (第1報)

ピリダチン類のヒドラチノ誘導体の合成

抄録

3-Methyl-6-hydrazinopyridazine (I) was prepared from 6-chloro compound (III) and hydrazine hydrate, almost in a quantitative yield. Reaction of the hydrochloride (m.p. 231° (decomp.)) of (I) and potassium thiocyanate gave the thiosemicarbazido compound, while that and cyanamide gave the hydrochloride of the aminoguanidino compound. Monochloroacetone and the former yielded 3-methyl-6-[N′-(4′-methylthiazolyl-2′)] hydrazinopyridazine, while γ-chloro-γ-acetopropyl alcohol and the same compound yielded 3-methyl-6-[N′-(4′-methyl-5′-β-hydroxyethylthiazolyl-2′)] hydrazinopyridazine, both as hydrochlorides.