チオバルビツール酸系静注麻酔剤の研究 (第4報)

チオペンタールソジウムの合成 その2

抄録

Ethyl (1-methylbutyl) ethylmalonate (XII) is an important intermediate for the preparation of Thiopental Sodium and is obtained by the pentylation of ethyl ethylmalonate (IX) but in a poor yield. Improvement was effected by carrying out the reaction in benzene series solvent and in the presence of metallic sodium, greatly increasing the yield. There are many methods of preparing Thiopental Sodium but the most advantageous is that through (VII)→(IX)→(XII)→(XIII)→(XIV). Hypnotic effect of Thiopental Sodium is far stronger than that of sodium 5-allyl-5-(Δ²-cyclohexenyl)-2-thiobarbiturate and sodium methylhexabital, and is most well adapted for intravenous anesthetic.