YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
1,3,4-Thiadiazole誘導体に関する研究 (第10報)
2,5-Dimethyl-1,3,4-thiadiazoleについて
大田 正樹木本 宏
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1956 年 76 巻 1 号 p. 10-12

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Reactivity of the two methyl groups in 2, 5-dimethyl-1, 3, 4-thiadiazole (I) was examined. (I) reacts with benzaldehyde to form a mono- and distyryl derivatives but the methiodide of (I) only forms a mono derivative with benzaldehyde, p-nitrobenzaldehyde, p-dimethylaminobenzaldehyde, or p-nitrosodimethylaniline. Application of bromoacetophenone or p-nitrobromoacetophenone to (I) affords a quaternary base and its treatment with alkali failed to yield the expected thiadiazolylpyrrole derivative, affording crystals assumed from its various properties to be the pseude base.

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