抄録
When boiled in pyridine, the Mannich bases obtained from paraformaldehyde, dimethylaniline hydrochloride, and acetophenones possessing nitro, chlorine, bromine, methyl, hydroxyl, or methoxyl as a substituent in the para-position, or unsubstituted, undergo substitution of the dimethylamino group with piperidino group. The yield of the reaction product, when the reaction was carried out under identical conditions, decreased in the order of methoxyl, hydroxyl, methyl, unsubstituted, chlorine, bromine, and nitro compounds. In general, ketonic Mannich bases possessing an electron donor group in the para-position of the benzene ring easily submit to amino exchange reaction but the reaction is difficult where there is an electron attracting group in such a position.
