ジアルキルアミノアチルアミノ誘導体の鎮痛作用 (第3報)

Isoamylα-〔N-(β-Dimethylaminoethyl)〕aminophenylacetate塩酸塩 (M-Avacan) の鎮痛作用に就いて

抄録

α-Dialkylaminoacyl and β-diethylaminoethyl derivatives of α-aminophenylaceto-nitrile and α-N-aralkylaminoacetyl and β-dimethylamino derivatives of isopropyl α-[N-(β-diethylaminoethyl)]aminophenylacetate hydrochloride (Avacan) were examined for analgesic activity. There was no anticipated decrease of toxicity or appearance of analgesic activity in the nitrile and its acyl derivatives, and their spasmolytic activity was inferior to that of Avacan. Local anesthetic action was not especially strong. However, β-dimethylamino derivative of Avacan (M-Avacan) showed large rise of the pain threshold compared to Avacan in both animal and human tests.