YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
含窒素環化合物の合成 (第102報)
3-アミノ-4-ヒドロキシピリジン誘導体, 2-アルキル (アリル) オキサツォロ〔4,5-c〕ピリジン及び2-チオオキサツォロ〔4,5-c〕ピリジン誘導体の合成
高橋 酉藏神代 昭
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1956 年 76 巻 12 号 p. 1388-1394

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1) 2-Alkyl (or aryl) oxazolo[4, 5-c]pyridines were prepared by the dry-distillation of 3-acylamino-4-hydroxypyridines obtained by the application of carboxylic acid, acid anhydride, or acid chloride to 3-amino-4-hydroxypyridine.
2) 2-Thioxazolo[4, 5-c]pyridine was prepared by warming methanolic solution of 3-amino-4-hydroxypyridine and potassium methylxanthogenate and its reaction with alkyl halide, ethyl halocarboxylate, and alkyl β-bromoethyl ether afforded the corresponding thioethers.
3) Attempt to obtain 2-aminoxazolo[4, 5-c]pyridine by the application of aqueous ethanolic solution of cyanogen bromide to 3-amino-4-hydroxypyridine ended fruitless and only 3-cyanoamino-4-hydroxypyridine was obtained.

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