Rats, 2-3 months old, were injected with 89Sr+90Sr (+90Y), without a carrier or with 0.5mg. of carrier-Sr, and then given repeated two injections without a carrier or seven (with carrier) injections of 50mg. of sodium rhodizonate. The animals were then sacrificed and excretion of radioactive strontium into urine and feces, and its deposition into the skeleton, kidneys, liver, spleen, lungs, and residual soft tissues were determined.
(1) When radioactive strontium was injected with a carrier, with subsequent administration of rhodizonate, the excretion of radioactive strontium into urine and feces was inhibited and its deposition into all the body tissues increased, especially in the kidneys where 37 times that in the control had deposited.
(2) When the radioactive strontium was injected without a carrier, with subsequent administration of rhodizonate, the excretion of radioactive strontium into the feces decreased and its deposition into the liver and kidneys increased. However, these tendencies were fairly limited and the distribution of radioactive strontium in the skleton, urine, and residual soft tissues excluding the kidneys and the liver, which determines the fate of the majority of radioactive strontium, was no different from that in the control.
