1956 年 76 巻 6 号 p. 640-644
2-Chloro-10-β-cyanoethylphenothiazine, obtained by the reaction 2-chlorophenothiazine and acrylonitrile, was submitted to catalytic reduction and 2-chloro-10-γ-aminopropylphenothiazine thereby obtained was methylated to 2-chloro-10-γ-dimethylaminopropylphenothiazine. Reduction in the presence of formylation agent afforded 2-chloro-10-γ-formamidopropylphenothiazine whose direct methylation afforded the 10-γ-dimethylamino derivative. Reduction with lithium aluminum hydride yielded the 10-γ-monomethylamino derivative. Methylation of bis-[2-chlorophenothiazinyl-(10)-propyl]amine, formed as a by-product, followed by the Hofmann degradation of its methiodide resulted in the recovery of 2-chloro-10-γ-dimethylaminopropylphenothiazine and 2-chloro-10-allylphenothiazine.