YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Phenothiazine誘導体の合成研究 (第2報)
10-β-Cyanoethylphenothiazineの還元について
藤井 輝一
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ジャーナル フリー

1956 年 76 巻 6 号 p. 640-644

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2-Chloro-10-β-cyanoethylphenothiazine, obtained by the reaction 2-chlorophenothiazine and acrylonitrile, was submitted to catalytic reduction and 2-chloro-10-γ-aminopropylphenothiazine thereby obtained was methylated to 2-chloro-10-γ-dimethylaminopropylphenothiazine. Reduction in the presence of formylation agent afforded 2-chloro-10-γ-formamidopropylphenothiazine whose direct methylation afforded the 10-γ-dimethylamino derivative. Reduction with lithium aluminum hydride yielded the 10-γ-monomethylamino derivative. Methylation of bis-[2-chlorophenothiazinyl-(10)-propyl]amine, formed as a by-product, followed by the Hofmann degradation of its methiodide resulted in the recovery of 2-chloro-10-γ-dimethylaminopropylphenothiazine and 2-chloro-10-allylphenothiazine.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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