YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
Phenothiazine誘導体の合成研究 (第3報)
10-β-Cyanoethylphenothiazineの二級アミン存在下の還元並びにβ-Cyanoethylamine誘導体の還元によるN,N´-Tetrasubstituted Propylenediamine誘導体の合成について
藤井 輝一
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ジャーナル フリー

1956 年 76 巻 6 号 p. 644-648

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Catalylic reduction of 2-chloro-10-β-cyanoethylphenothiazine in the presence of dimethylamine afforded 2-chloro-10-γ-dimethylaminopropylphenothiazine. The same reduction in the presence of diethylamine, piperidine, or morpholine yielded the corresponding homologs. In these cases, the 10-γ-aminopropyl derivative and bis [2-chlorophenothiazinyl-(10)-propyl] amine were invariably formed as by-products. Reaction of carbazole, indole, or benzimidazole with acrylonitrile gave the N-β-cyanoethyl derivatives whose reduction in the presence of dimethylamine afforded N-γ-dimethylaminopropyl derivatives.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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