セリ科植物成分の研究 (第1報)

ウドモドキ根の成分 その1

抄録

A new coumarin derivative was isolated from the root of Angelica glabra MAKINO (family Umbelliferae) and was named glabralactone (I). This plant is an allied species of A. pubescens and is different from A. dahurica (FISCH.) BENTH., which had been reported as A. glabra MAKINO and yields byak-angelicin, a furocoumarin derivative. (I) comes as crystals melting at 129-130° and agrees with the molecular formula C₁₆H₁₆O₅; it gives negative ferric chloride reaction, decolorizes permanganate and bromine; forms an adduct with hydroxylamine, and forms a dihydro compound (III) by catalytic reduction. Potash fusion of (III) affords phloroglucinol, acetic acid, and isovaleric acid, while heating of (I) with acetic acid added with sulfuric acid gives 5, 7-dimethoxycoumarin (IV) and γ, γ-dimethylacrylic acid (V). It follows, therefore, that (I) is formed by the bonding of the acid residue (V) to the benzene ring of (IV).