YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
胎盤中の性腺刺激ホルモンに関する化学的研究 (第1報)
胎盤より性腺刺激ホルモンの抽出及び精製
松島 早苗難波 脩二
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1956 年 76 巻 6 号 p. 678-681

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Villus gonadotrophic hormone is secreted from the villus tissues of the placenta and excreted in a large amount into the urine. Its isolation is chiefly made from the the urine of a pregnant woman and no attempt has been made to isolate it directly from the placenta itself. In order to study the chemical difference between the gonadotrophic hormone isolated from the urine and that from the placenta, examination was first made for the method of isolating the said hormone from the placenta in a high purity. General method of extracting and purifying proteins was applied to human placenta and the crude product obtained by extraction with ammonia water and precipitation with ethanol was extracted at pH 4.8 with 50% ethanol. This was found to give the best yield of a highly pure product of 400-600 I. U./mg.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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