YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
結核化学療法の研究 第9報
Alkyl化合物の物理化学的性質と結核菌に対する抗菌作用との関係 その1
渡邊 煕
著者情報
ジャーナル フリー

1956 年 76 巻 6 号 p. 696-701

詳細
抄録

Investigations to date indicate that the relationship between the number of carbon atoms in the alkyl of alkylated compounds and their antibacterial power against tubercle bacilli can be indicated by a heaped curve. The antibacterial power increases with the increasing number of the carbon in alkyl group, reaches a maximum, and decreases with further increase of the alkyl chain. In order to analyse this curve, relationship between the physicochemical properties of the compounds and length of their alkyl chain, was examined, together with its correlation to antibacterial power. It was thereby concluded that the increase in antibacterial power with increasing number of carbon chain is due to gradual increase of adsorptive ability of the compounds on bacterial surface, while the decrease is due to gradual decrease of the penetrability on the bacterial surface. The height of the curve is limited by the parental structure of the homologs and abnormal phenomena can be well explained by this assumption.

著者関連情報
© by the PHARMACEUTICAL SOCIETY OF JAPAN
前の記事 次の記事
feedback
Top