YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
チオアセタゾーンの体内変化に関する研究 (第4報)
チオアセタゾーンの消化器管中における分解について
有田 隆一
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ジャーナル フリー

1956 年 76 巻 9 号 p. 990-993

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Decomposition of p-acetylaminobenzaldehyde thiosemicarbazone (thioacetazone) in the digestive tract was examined by paper chromatography. Thioacetazone is decomposed into p-acetylaminobenzaldehyde and thiosemicarbazode in artificial gastric juice and is also deacetylated to form p-aminobenzaldehyde thiosemicarbazone. Its decomposition in the intestines was examined with artificial enteric juice, duodenal mucous enzyme from a rabbit and bovine, and intestinal flora (Escherichia coli communior, Streptococcus faecalis, and Lactobacillus acidophilus). No change occurred in artificial enteric juice and Escherichia coli, but thioacetazone was deacetylated by intestinal mucous enzyme, Strept. faecalis, and Lact. acidophilus. p-Acetylaminobenzaldehyde was also found to be deacetylated by the Lactobacilli.

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© by the PHARMACEUTICAL SOCIETY OF JAPAN
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