主薬の界面活性化 (第1報)

高級アルキルサルフェイトに就いて

抄録

In order to increase the stability, emulsifiability, and dispersibility of main drugs and to decrease their irritant properties, attempts were made to give surface active properties to the main drugs. Higher alkylsulfates of antihistamines like 2-dimethylaminoethyl benzhydryl ether, antimicrobial agents like 2-dimethylamino-6-(2-diethylaminoethoxy) benzothiazole, and local anesthetics like 2-diethylaminoethyl p-aminobenzoate (procaine) were synthesized and their surface tension was measured. At the same time, emulsification test was carried out and it was found that they had better surface activity than the free bases, hydrochlorides, and other mineral acid salts. It was observed that the surface activity and emulsifiability became the greatest when the number of carbon atoms in the alkyl group of alkylsulfates was around 12-14. A good result was obtained in the emulsification of liquid paraffin and water by the use of laurylsulfate of 2-dimethylaminoethyl benzhydryl ether, with the addition of a minute amount of alkali.