アンチビタミンの微生物に及ぼす影響 (第1報)

2-Methyl-4-amino-5-hydroxymethylpyrimidineの乳酸菌増殖阻害とビタミンによる回復

抄録

In order to examine the effect of antipyridoxine substances on microörganisms, growth inhibition by 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP) of five kinds of Lactobacteriaceae, Lactobacillus arabinosus, L. casei, L. fermenti, Leuconostoc mesenteroides, and Streptococcus faecalis, was examined in a vitamin-deficient medium containing a minimum amount of requisite vitamins. With the exception of L. arabinosus, growth of all four organisms of Lactobactriaceae was inhibited by OMP in concentrations above 10-100γ/tube. Recovery of growth inhibition was examined by adding various kinds of vitamins with OMP and it was found that only the pyridoxine group vitamins exhibited specific antagonism against OMP. Such observations agree with the results obtained so far with mice, rats, and yeast. It was considered that the reason why L. arabinosus growth was not inhibited by OMP is because this bacillus can biosynthesize pyridoxine.