アンチビタミンの微生物に及ぼす影響 (第4報)

乳酸菌増殖阻害のアトキソピリミジンによる回復

抄録

It has been reported that compounds structurally related to 2-methyl-4-amino-5-hydroxymethylpyrimidine (OMP) are antagonistic to OMP against spasms in mice. According to experiments in growth inhibition of organisms of Lactobacteriaceae, using vitamin-deficient medium, such substances as 2-methyl-4-amino-5-aminomethyl-, 2-methyl-4-hydroxy-5-hydroxymethyl-, and 2-methyl-4-hydroxy-5-amino-methylpyrimidine were not antagonistic to OMP. 2-Methyl-4-hydroxy-5-aminomethylpyrimidine showed a slight antagonism against St. faecalis in 1mg./tube amount but from its weaker recovery and larger amount needed in comparison with antagonism by 1γ/tube of pyridoxine, it could not be considered as the antagonist of OMP.