Arylalkylamine類の合成研究 (第2報)

1-(2-Methoxyphenyl)-2-propanoneの合成

抄録

1-(2-Methoxyphenyl)-2-propanone was prepared by several methods for a starting material for α-methyl-2-methoxyphenethylanine and comparative examinations were made on the following three methods. (1) Hydrolysis and decarboxylation of 2-(2-methoxyphenyl)-2-acetylacetonitrile (2) condensation of (2-methoxyphenyl) acetyl chloride and ethyl ethoxymagnesiomalonate, followed by hydrolysis and decarboxylation, or a reaction of the acid chloride and dimethylcadmium, and (3) reaction of 2-propenylanisole and peracetic or performic acid and hydrolysis of its product with dilute acid, or alkali treatment of acetoxyl derivative of 2-propenylanisole pseudonitrosite to form 1-(2-methoxyphenyl)-2-nitropropene and its reductive hydrolysis with iron and hydrochloric acid.