Vitamin B₁及び諸関係化合物の研究 第86報

Disulfide型thiamine誘導体の熱分解について その5

抄録

The formation of thiochrome (VII) during the decomposition of thiamine-disulfide (I) is thought not to pass through dihydrothiochrome (VI). The hydroxyl group attached to the ethyl group bonded to the β-position of N-vinylene in symmetrical disulfide derivatives and the hydroxyl group in the alkyl bonded to the disulfide in asymmetrical disulfide derivatives bear important significance in the formation of thiaminethiazolone (IV) and thiochrome (VII), since the presence of the hydroxyl effects progress of the decomposition reaction towards the formation of (IV), while the absence of hydroxyl group or the substitution of the hydrogen with alkyl group effects progress of the reaction towards formation of (VII).